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Neurotransmitter Modulation: 4-CL-PVP crystals are noted to have an affect on the amounts of specified neurotransmitters while in the brain, for example dopamine and norepinephrine.

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As chlorine is very electrophilic the profile of electrostatic demand all over the molecule will probably be altered, once and for all or negative. Sterically it may even alter binding, but once again substitutions while in the para placement have already been properly tolerated in other cathinones including 4 MMC.

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